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Selected Publication:
Adam, P; Katzenberger, T; Seeberger, H; Gattenlöhner, S; Wolf, J; Steinlein, C; Schmid, M; Müller-Hermelink, HK; Ott, G.
A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation.
Am J Surg Pathol. 2003; 27(11):1473-1476
Doi: 10.1097/00000478-200311000-00012
(- Case Report)
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- Co-authors Med Uni Graz
- Gattenlöhner Stefan
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- Abstract:
- Anaplastic large cell lymphomas are associated with the t(2;5)(p23;q35) chromosome translocation in 40% to 60% of cases, leading to a new chimeric gene NPM-ALK. NPM-ALK positive lymphomas are generally reported to be of either T cell or null phenotype. In this report, we describe a diffuse large B-cell lymphoma associated with the classic t(2;5) translocation and both nuclear and cytoplasmic expression of ALK. The tumor consisted of medium-sized to large immunoblasts and plasmablasts that on immunohistology were negative for CD30, CD20, and CD79a but showed monotypic cytoplasmic expression of lambda light chains. Clonality analysis confirmed B-cell lineage of the tumor cells. The t(2;5)(p23;q35) chromosome translocation was demonstrated as part of a complex karyotypic alteration by classic banding and spectral karyotyping (SKY) analyses. Reverse transcription polymerase chain reaction confirmed rearrangement of NPM and ALK genes. This case exemplifies that the t(2;5) can, albeit rarely, occur in large B-cell lymphomas and is not entirely limited to anaplastic large cell lymphomas of T or null cell phenotypes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Chromosomes, Human, Pair 2 -
- Chromosomes, Human, Pair 5 -
- DNA, Neoplasm - analysis
- Humans -
- Immunohistochemistry -
- Lymphoma, B-Cell - genetics
- Lymphoma, Large B-Cell, Diffuse - genetics
- Male -
- Protein-Tyrosine Kinases - genetics
- Receptor Protein-Tyrosine Kinases -
- Reverse Transcriptase Polymerase Chain Reaction -
- Spectral Karyotyping -
- Translocation, Genetic -
- Find related publications in this database (Keywords)
- DLBL
- ALK
- t(2
- )
- B phenotype