Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Muller-Richter, UDA; Dowejko, A; Peters, S; Rauthe, S; Reuther, T; Gattenlohner, S; Reichert, TE; Driemel, O; Kubler, AC.
MAGE-A antigens in patients with primary oral squamous cell carcinoma.
Clin Oral Investig. 2010; 14(3):291-296
Doi: 10.1007/s00784-009-0292-2
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Gattenlöhner Stefan
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- Abstract:
- MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Neoplasm - analysis
- Blood Vessels - immunology
- Carcinoma, Squamous Cell - immunology
- Cohort Studies -
- Female -
- Humans -
- Immunohistochemistry -
- Lymphatic Metastasis - immunology
- Lymphatic Vessels - immunology
- Male -
- Melanoma-Specific Antigens -
- Mouth Neoplasms - immunology
- Neoplasm Invasiveness -
- Neoplasm Proteins - analysis
- Neoplasm Staging -
- Retrospective Studies -
- Sex Factors -
- Find related publications in this database (Keywords)
- MAGE-A antigens
- Immunotherapy
- Oral squamous cell carcinoma
- Tumor antigens