Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Cam, H; Griesmann, H; Beitzinger, M; Hofmann, L; Beinoraviciute-Kellner, R; Sauer, M; Huttinger-Kirchhof, N; Oswald, C; Friedl, P; Gattenlohner, S; Burek, C; Rosenwald, A; Stiewe, T.
p53 family members in myogenic differentiation and rhabdomyosarcoma development.
Cancer Cell. 2006; 10(4):281-293
Doi: 10.1016/j.ccr.2006.08.024
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- Co-authors Med Uni Graz
- Gattenlöhner Stefan
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- Abstract:
- The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. DeltaNp73 inhibits these functions of the p53 family in differentiation control, prevents myogenic differentiation, and enables cooperating oncogenes to transform myoblasts to tumorigenicity. DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Differentiation - genetics
- Cell Line -
- Gene Expression Regulation, Neoplastic -
- Genes, p53 -
- Humans -
- Immunohistochemistry -
- Mice -
- Mice, Nude -
- Muscle, Skeletal - cytology Muscle, Skeletal - physiology
- Oligonucleotide Array Sequence Analysis -
- Rhabdomyosarcoma - genetics Rhabdomyosarcoma - pathology
- Tumor Suppressor Protein p53 - analysis
- Xenograft Model Antitumor Assays -