Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Richtig, E; Komericki, P; Trapp, M; Ott, A; Bisail, B; Egger, JW; Zalaudek, I.
Ratio of marked and excised sentinel lymph nodes and scintigraphic appearance time in melanoma patients with negative sentinel lymph node.
Eur J Surg Oncol. 2010; 36(8):783-788
Doi: 10.1016/j.ejso.2010.05.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Richtig Erika
- Co-Autor*innen der Med Uni Graz
- Egger Josef Wilhelm
- Komericki Peter
- Ott Arthur
- Trapp Michael
- Zalaudek Iris
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- Abstract:
- Metastases can occur in up to 15% of all melanoma patients with negative sentinel lymph node examination (SN -). We retrospectively investigated the number of preoperatively marked sentinel lymph nodes (SNs) with lymphoscintigraphy and effectively surgically removed SNs in SN--patients with cutaneous melanoma >or=0.5 mm. Ratio of these parameters was calculated and impact of this ratio as well as impact of scintigraphic appearance time (SAT) on disease progression was studied. Data on 122 SN--patients--70 women (58%), mean age 56.5 years--were analyzed. Mean follow-up time was 58 months. Mean tumour thickness of all patients was 2.3 mm. In 51 patients (42%) the number of SNs marked in lymphoscintigraphy was higher than excised in surgery, in 47 patients (38%) the same number as marked was excised and in 24 patients (20%) a lower number was marked than excised. Metastases occurred in 17 patients (14%) after a mean time of 24.8 months. Mean tumour thickness (5.4 mm) was significantly higher in these patients than in the other patients (p = 0.000). Ratio of marked and excised SNs had no influence on disease progression; the only parameter influencing outcome was tumour thickness (p = 0.000). Short SAT was significantly associated with higher tumour thickness (p = 0.004). Our study indicates that, in routine clinical practice, it suffices to harvest the first SN, as the ratio of marked and excised SNs has no impact on disease progression. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Disease Progression -
- Female -
- Humans -
- Lymph Nodes - diagnostic imaging
- Lymph Nodes - pathology
- Lymph Nodes - surgery
- Lymphatic Metastasis - diagnostic imaging
- Male -
- Melanoma - diagnostic imaging
- Melanoma - pathology
- Melanoma - surgery
- Middle Aged -
- Radionuclide Imaging -
- Retrospective Studies -
- Sentinel Lymph Node Biopsy - methods
- Skin Neoplasms - diagnostic imaging
- Skin Neoplasms - pathology
- Skin Neoplasms - surgery
- Young Adult -
- Find related publications in this database (Keywords)
- Negative sentinel lymph node biopsy
- Melanoma
- Metastasis
- lymphoscintigraphy
- Scintigraphic appearance time