Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fitzgerald, JS; Germeyer, A; Huppertz, B; Jeschke, U; Knofler, M; Moser, G; Scholz, C; Sonderegger, S; Toth, B; Markert, UR.
Governing the invasive trophoblast: current aspects on intra- and extracellular regulation.
AMER J REPROD IMMUNOL. 2010; 63(6): 492-505.
Doi: 10.1111/j.1600-0897.2010.00824.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
- Moser Gerit
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a possible mechanism for opening and connecting uterine glands into the intervillous space. Amongst others, two intracellular signalling pathways are crucial for regulation of trophoblast functions and development: Wnt- and signal transducer and activator of transcription (STAT)3 signalling. Wnt signalling promotes implantation, placentation and trophoblast differentiation. Several Wnt-dependent cascades and regulatory mechanisms display different functions in trophoblast cells. The STAT3 signalling system is fundamental for induction and regulation of invasiveness in physiological trophoblastic cells, but also in tumours. The role of galectins (Gal) in trophoblast regulation and placenta development comes increasingly into focus. The Gal- 1-4, 7-10 and 12-14 have been detected in humans. Detailed information is only available for Gal-1, -2, -3, -4, -9 and -12 in endometrium and decidua. Gal-1, -3 and -13 (-14) have been detected and studied in trophoblast cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Decidua - metabolism
- Female -
- Humans -
- Intercellular Signaling Peptides and Proteins - metabolism
- Intracellular Signaling Peptides and Proteins - metabolism
- Mice -
- Placenta - growth and development
- Pregnancy -
- Signal Transduction -
- Trophoblasts - cytology
- Find related publications in this database (Keywords)
- Decidua
- galectins
- matrix metalloproteinases
- signal transducer and activator of transcription 3
- tissue inhibitors of metalloproteinases
- trophoblast cells
- Wnt signalling