Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gruber, HJ; Bernecker, C; Lechner, A; Weiss, S; Wallner-Blazek, M; Meinitzer, A; Hobarth, G; Renner, W; Fauler, G; Horejsi, R; Fazekas, F; Truschnig-Wilders, M.
Increased nitric oxide stress is associated with migraine.
CEPHALALGIA. 2010; 30(4): 486-492.
Doi: 10.1111/j.1468-2982.2009.01964.x
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Gruber Hans-Jürgen
- Co-Autor*innen der Med Uni Graz
- Bernecker Claudia
- Fauler Günter
- Fazekas Franz
- Hoebarth Gerhard
- Horejsi Renate
- Lechner Anita
- Meinitzer Andreas
- Renner Wilfried
- Truschnig-Wilders Martini
- Wallner-Blazek Mirja
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- Abstract:
- Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine remains unclear. We here hypothesize that increased NO in the headache-free period is associated with migraine. One hundred and thirty probands participated in this study. Various parameters of the NO pathway, such as nitrate, nitrite, arginine, citrulline, nitrosylated proteins, asymmetric dimethylarginine, symmetrical dimethylarginine, expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase and two polymorphisms of eNOS were investigated. We found significant increased nitrate and decreased nitrite levels in migraineurs in the headache-free period. Nitrate and nitrite levels showed a significant inverse correlation. Logistic regression revealed an odds ratio of 3.6 for migraine. Other parameters of the NO pathway were neither altered in migraineurs nor correlated with nitrate. We show here that migraine patients suffer under sustained increased nitrosative stress in the headache-free period, which is associated with a 3.6-fold higher risk for migraine.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Amidohydrolases - blood
- Arginine - analogs and derivatives
- Female -
- Humans -
- Male -
- Migraine with Aura - epidemiology
- Nitrates - blood
- Nitric Oxide - blood
- Nitric Oxide Synthase Type II - genetics
- Nitric Oxide Synthase Type III - genetics
- Nitrites - blood
- Polymorphism, Genetic -
- Risk Factors -
- Stress, Physiological - physiology
- Find related publications in this database (Keywords)
- Migraine
- aura
- nitric oxide
- NOS
- ADMA