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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Heratizadeh, A; Killig, C; Worm, M; Soost, S; Simon, D; Bauer, A; Mahler, V; Schuster, C; Szliska, C; Frambach, Y; Eben, R; Werfel, T; Uter, W; Schnuch, A.
Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients: results of the IVDK
CONTACT DERMATITIS. 2010; 62(6): 330-337. Doi: 10.1111/j.1600-0536.2010.01726.x
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Co-Autor*innen der Med Uni Graz: Schuster Christian Josef
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Abstract:: Background: While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. Objective: The objective of this study was to find a maximum non-eliciting concentration for rinse-off products in MDBGN patch test-positive patients. Patients and methods: We performed a use-related test [repeated open application test (ROAT)] in patients sensitized to MDBGN with a liquid soap containing three concentrations of MDBGN (50, 200, and 400 p. p. m. MDBGN, respectively). The soap at 50 p. p. m. was used twice daily for 4 weeks. If no reaction of the skin was observed, the product with the next higher concentration was used for another 4 weeks, etc. Results: In total, 32/37 evaluated cases [86.5%; lower exact one-sided 95% confidence limit (CL): 73.7%] did not react to any of the preparations. The remaining reacted as follows: 1/37 reacted to 50 p. p. m., 3/37 to 200 p. p. m., and 1/37 to 400 p. p. m. The cumulative non-response to 50 p. p. m. was 97.3% (lower CL: 87.8%). Conclusions: The majority of subjects sensitized to MDBGN-tolerated rinse-off products containing a maximum concentration of 400 p. p. m. A concentration in rinse-off products in the range of 50 p. p. m. could be regarded as safe for most individuals already sensitized. These concentrations will presumably prevent induction (sensitization) also.
Find related publications in this database (Keywords): CAS 35691-65-7; consumer safety; methyldibromo glutaronitrile; patch testing technique; rinse-off cosmetics; ROAT; use test