Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rinner, B; Kretschmer, N; Knausz, H; Mayer, A; Boechzelt, H; Hao, XJ; Heubl, G; Efferth, T; Schaider, H; Bauer, R.
A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner.
J Ethnopharmacol. 2010; 129(2):182-188
Doi: 10.1016/j.jep.2010.02.006
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Rinner Beate
- Co-Autor*innen der Med Uni Graz
- Knausz Heike
- Kretschmer Nadine
- Mayer Andrea
- Schaider Helmut
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- Abstract:
- Traditional Chinese medicine (TCM) has become very popular in Western countries during the last years. Zicao, a remedy of TCM, has been traditionally used to treat cancer, and, its main constituents, naphthoquinones, have been reported to possess antitumor activity (Chen et al., 2002; Papageorgiou et al., 1999). Here, we prepared extracts of different polarities of Onosma paniculatum Bur. & Franch., a plant which is amongst others used as Zicao, but, much less investigated. The extracts were analyzed concerning their growth inhibitory and apoptosis-inducing activity in various tumor cells. Cell viability was measured by XTT viability and a growth inhibition assay. Effects on the cell cycle and caspase-3 were determined by flow cytometry. From three different extracts, a petrol ether extract showed significant growth inhibitory effect, cell cycle influence and caspase-3 dependent induction of apoptosis which was time and dose dependent. To further determine the activity and mechanism of action of the petrol ether extract, we would like to isolate and identify the active principle and investigate the effects in more detail. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Phytogenic - isolation & purification
- Antineoplastic Agents, Phytogenic - pharmacology
- Antineoplastic Agents, Phytogenic - therapeutic use
- Apoptosis - drug effects
- Boraginaceae - chemistry
- Caspase 3 - metabolism
- Cell Cycle - drug effects
- Cell Line, Tumor -
- Cell Proliferation - drug effects
- Dose-Response Relationship, Drug -
- Drugs, Chinese Herbal - isolation & purification
- Drugs, Chinese Herbal - pharmacology
- Drugs, Chinese Herbal - therapeutic use
- Ether -
- Humans -
- Neoplasms - drug therapy
- Neoplasms - metabolism
- Phytotherapy -
- Plant Roots -
- Find related publications in this database (Keywords)
- Onosma paniculatum
- Zicao
- Cancer
- Cell cycle
- Caspase-3