Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Augustin, H; Isbarn, H; Auprich, M; Bonstingl, D; Al-Ali, BM; Mannweiler, S; Pummer, K.
Head to head comparison of three generations of Partin tables to predict final pathological stage in clinically localised prostate cancer.
Eur J Cancer. 2010; 46(12): 2235-2241.
Doi: 10.1016/j.ejca.2010.04.013
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Augustin Herbert
- Co-Autor*innen der Med Uni Graz
- Auprich Marco
- Mannweiler Sebastian
- Mohamad Al-Ali Badereddin
- Pummer Karl
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Objective: To perform a head to head comparison between three generations of Partin tables, namely from 1997, 2001 and the last updated version of 2007. Material and methods: The external validations were based on clinical and pathological data of 687 consecutive patients undergoing radical prostatectomy for clinically localised prostate cancer between 2003 and 2008. Three versions of the Partin tables were compared for their accuracy and performance to predict final pathological stage using receiver operating characteristic (ROC) curve and Loess plots analyses. Results: Of the whole cohort, 76.2% of men were presented with organ-confined disease (OC), 17.0% had extraprostatic extension (ECE), 6.0% showed seminal vesicle involvement (SVI) and 1.2% had lymph node involvement (LNI). The area under the receiver operating characteristic curve (AUC) of the Partin Tables 1997, 2001 and 2007 was 0.731, 0.727 and 0.722 for OC; 0.671, 0.662 and 0.650 for ECE; 0.795, 0.788 and 0.779 for SVI as well as 0.826, 0.786 and 0.746 for LNI, respectively. Conclusion: All three generations of the Partin tables showed a good accuracy to predict OC, SVI and LNI. However, the predictive accuracy for ECE was only modest. Overall, the newer versions of the Partin tables could not exceed the version of 1997 in their predictive accuracy for any pathological stage and they failed to demonstrate a clear advantage. Our results underline the necessity to perform external validations before the implementation of a new predicting tool. (C) 2010 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Epidemiologic Methods -
- Humans -
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Invasiveness - pathology
- Neoplasm Staging -
- Prostate-Specific Antigen - blood
- Prostatic Neoplasms - blood
- Seminal Vesicles - pathology
- Find related publications in this database (Keywords)
- Nomogram
- Partin tables
- Prostate cancer
- Radical prostatectomy