Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pristauz, G; Geigl, JB; Petru, E.
BRCA1- and BRCA2 mutations: Clinical management of patients with hereditary breast and ovarian cancer.
Wien Med Wochenschr. 2010; 160(7-8): 158-162.
Doi: 10.1007/s10354-010-0772-7
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pristauz-Telsnigg Gunda
- Co-Autor*innen der Med Uni Graz
- Geigl Jochen Bernd
- Petru Edgar
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: In total, 5-10% of all breast cancer cases are related to gen mutations. In most cases a mutation in the BRCA1-gen and BRCA2-gen is responsible for insufficient repair of DNA damages that cause breast and ovarian cancer. CLINICAL MANAGEMENT: In patients carrying BRCA1-mutation the risk for developing breast and ovarian cancer is 87% and 40% as well as 47% and 20% for those carrying a BRCA2-mutation. Women at hereditary risk should be informed about existing recommendations for surveillance. Primary prevention of breast and ovarian cancer including prophylactic surgery (bilateral salpingoophorectomy and bilateral mastectomy) should be explained to mutation carriers. The issue of oral antihormonal therapy for prevention of breast cancer should be addressed. Psycho-social support should be offered to mutation carriers. CONCLUSIONS: The clinical management of BRCA1 and BRCA2-mutation carriers is very challenging and should be done in centres specialized in this issue.
- Find related publications in this database (using NLM MeSH Indexing)
- Apoptosis Regulatory Proteins -
- BRCA2 Protein - genetics
- Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - prevention and control Breast Neoplasms - therapy
- Cooperative Behavior -
- DNA Mutational Analysis -
- Female -
- Genetic Predisposition to Disease - genetics
- Genetic Testing -
- Heterozygote Detection -
- Humans -
- Interdisciplinary Communication -
- Male -
- Mastectomy -
- Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - prevention and control Neoplasms, Multiple Primary - therapy
- Ovarian Neoplasms - diagnosis Ovarian Neoplasms - genetics Ovarian Neoplasms - prevention and control Ovarian Neoplasms - therapy
- Ovariectomy -
- Prognosis -
- Risk -
- Ubiquitin-Protein Ligases - genetics