Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brunner, M; Thurnher, D; Pammer, J; Heiduschka, G; Petzelbauer, P; Schmid, C; Schneider, S; Erovic, BM.
Expression of hedgehog signaling molecules in Merkel cell carcinoma.
Head Neck. 2010; 32(3):333-340
Doi: 10.1002/hed.21191
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schmid Christoph Michael
- Thurnher Dietmar
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- Abstract:
- The Hedgehog signaling pathway is important for human development and carcinogenesis in various malignancies. One tissue microarray with triplets of 28 samples from 25 patients with Merkel cell carcinoma (MCC) was constructed. Six samples of normal skin and 5 samples of normal oral mucosa served as controls. All samples were analyzed immunohistochemically with antibodies directed against Sonic hedgehog, Indian hedgehog, Patched, Smoothened, Gli-1, Gli-2, and Gli-3. All investigated proteins were frequently and intensely overexpressed in MCCs (Sonic hedgehog, 93%; Indian hedgehog, 84%; Patched, 86%; Smoothened, 79%; Gli-1, 79%; Gli-2, 79%; Gli-3, 86%) compared with control samples. High levels of Patched and Indian hedgehog were significantly associated with an increase in patients overall (p = .015) and recurrence-free survival (p = .011), respectively. Our results indicate that the Hedgehog signaling pathway is strongly activated in MCC and thus may play a role in carcinogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Carcinoma, Merkel Cell - metabolism
- Carcinoma, Merkel Cell - mortality
- Carcinoma, Merkel Cell - pathology
- Case-Control Studies -
- Cohort Studies -
- Female -
- Head and Neck Neoplasms - metabolism
- Head and Neck Neoplasms - mortality
- Head and Neck Neoplasms - pathology
- Hedgehog Proteins - metabolism
- Humans -
- Kruppel-Like Transcription Factors - metabolism
- Male -
- Middle Aged -
- Nerve Tissue Proteins - metabolism
- Nuclear Proteins - metabolism
- Patched Receptors -
- Receptors, Cell Surface - metabolism
- Receptors, G-Protein-Coupled - metabolism
- Skin Neoplasms - metabolism
- Skin Neoplasms - mortality
- Skin Neoplasms - pathology
- Smoothened Receptor -
- Transcription Factors - metabolism
- Zinc Finger Protein GLI1 -
- Find related publications in this database (Keywords)
- Merkel cell carcinoma
- Patched
- Smoothened hedgehog
- Indian hedgehog
- Sonic hedgehog