Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kniepeiss, D; Wagner, D; Wirnsberger, G; Roller, RE; Wasler, A; Iberer, F; Tscheliessnigg, KH.
Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients.
J Thorac Cardiovasc Surg. 2010; 140(3):688-693
Doi: 10.1016/j.jtcvs.2010.03.031
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- Führende Autor*innen der Med Uni Graz
- Kniepeiss Daniela
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Roller-Wirnsberger Regina
- Tscheliessnigg Karlheinz
- Wagner Doris
- Wasler Andrae
- Wirnsberger Gerhard
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- Abstract:
- With the increasing longevity of heart transplant recipients, the long-term effects of cyclosporine on renal function have become more evident. Highly sensitive, early, and effective monitoring of posttransplant renal function is still being researched. This study aimed to evaluate the prognostic value of cystatin C for patients after heart transplantation. Seventy-three long-term recipients of a heart transplant more than 5 years before the study start were included in the analysis with a follow-up of 4 years. Serum creatinine, renal glomerular filtration rate calculated by the Modification of Diet in Renal Disease formula, and serum cystatin C levels were collected, and risk factors for renal dysfunction were assessed. Statistical analysis was performed for all patients. Univariate analysis showed a prognostic impact of antihypertensive medication and onset of diabetes (P < .001) on renal failure after transplantation. Multivariate analysis yielded cystatin C measured at the study start as a superior prognostic parameter for all time points (area under the receiver operating characteristic 12 months: 0.963; 24 months: 0.910; 48 months: 0.949) compared with the conventionally used creatinine levels. Our results showed an enormous potential of serum cystatin C as an early prognostic and easy to obtain biomarker for renal dysfunction after heart transplantation. 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged -
- Biomarkers - blood
- Creatinine - blood
- Cystatin C - blood
- Drug Therapy, Combination -
- Early Diagnosis -
- Female -
- Follow-Up Studies -
- Glomerular Filtration Rate -
- Heart Transplantation - adverse effects
- Humans -
- Hypertension, Renal - blood Hypertension, Renal - chemically induced Hypertension, Renal - diagnosis Hypertension, Renal - physiopathology
- Immunosuppressive Agents - adverse effects
- Logistic Models -
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- ROC Curve -
- Renal Insufficiency - blood Renal Insufficiency - chemically induced Renal Insufficiency - diagnosis Renal Insufficiency - physiopathology
- Risk Assessment -
- Risk Factors -
- Time Factors -
- Treatment Outcome -