Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stauber, RE; Olschewski, H.
Portopulmonary hypertension: short review
EUR J GASTROENTEROL HEPATOL. 2010; 22(4): 385-390.
Doi: 10.1097/MEG.0b013e3283337130
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- Führende Autor*innen der Med Uni Graz
- Stauber Rudolf
- Co-Autor*innen der Med Uni Graz
- Olschewski Horst
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- Abstract:
- Portopulmonary hypertension (PoPH) is an underrecognized complication of portal hypertension, related to cirrhosis and noncirrhotic portal hypertension. PoPH has been found in 5-6% of patients with decompensated liver disease and may adversely affect outcome after liver transplantation. The prevalence of PoPH is unrelated to the severity of liver disease but associated with female sex and underlying autoimmune liver disease. Diagnosis of PoPH is based on screening with Doppler echocardiography and confirmation by right-heart catheterization. Treatment options with proven efficacy in idiopathic pulmonary hypertension include endothelin receptor antagonists, prostanoids, and sildenafil. In PoPH, such targeted treatment was found to be safe in small uncontrolled studies but randomized trials demonstrating its benefit are lacking.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms -
- Humans -
- Hypertension, Portal - complications
- Hypertension, Pulmonary - complications
- Liver Transplantation - adverse effects
- Piperazines - therapeutic use
- Prostaglandins - therapeutic use
- Purines - therapeutic use
- Receptors, Endothelin - antagonists and inhibitors
- Sex Factors -
- Sulfones - therapeutic use
- Vasodilator Agents - therapeutic use
- Find related publications in this database (Keywords)
- cirrhosis
- endothelin receptor antagonists
- liver transplantation
- portal hypertension
- pulmonary hypertension