Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Perl, S; Schmolzer, I; Sourij, H; Pressl, H; Eder, M; Zweiker, R; Wascher, TC.
Telmisartan improves vascular function independently of metabolic and antihypertensive effects in hypertensive subjects with impaired glucose tolerance.
INT J CARDIOL. 2010; 139(3): 289-296.
Doi: 10.1016/j.ijcard.2008.10.048
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Perl Sabine
- Wascher Thomas
- Co-Autor*innen der Med Uni Graz
- Pressl Helga
- Sourij Harald
- Steinberger Michaela
- Zweiker Robert
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- Abstract:
- Background: Hypertensive patients with IGT have increased risk for cardiovascular disease and progression to diabetes mellitus. Clinical trials suggest that the ARB telmisartan uniquely possesses PPAR gamma agonistic properties and improves insulin resistance as well as vascular endothelial dysfunction. The aim of the present study was to compare vascular effects of telmisartan and losartan in relation to their metabolic and antihypertensive effects in hypertensive patients with IGT. Materials and methods: 24 patients were randomised in a double-blind, prospective, cross-over trial. At baseline and after 12 weeks of either treatment an oGTT, and endothelial function testing was performed. Results: Endothelial function improved significantly by telmisartan treatment but not by losartan treatment (FMD; T: 7.9 +/- 0.7%, vs B: 6.4 +/- 0.8, p < 0.01; vs L: 6.4 +/- 0.6, p < 0.001) at almost identical antihypertensive effect of both agents. Insulin resistance assessed by HOMA (T: 2.20 +/- 0.47 vs B: 3.04 +/- 0.60, p < 0.01; vs L: 3.38 +/- 0.84, T vs L p < 0.05) and ISI120 (T: 0.114 +/- 0.003 vs B: 0.092 +/- 0.002, p < 0.001; vs L: 0.090 +/- 0.006, T vs L p < 0.01) improved significantly after telmisartan only, as did glucose tolerance (p < 0.01). The improvement of the endothelial function observed, significantly depended on pretreatment insulin resistance but was independent of improvements of insulin resistance, blood pressure or glucose tolerance. Conclusion: In hypertensive patients with IGT telmisartan compared to losartan improved endothelial function and insulin resistance independently, supporting the hypothesis that glucometabolic and vascular insulin resistance are differentially regulated. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use
- Benzimidazoles - therapeutic use
- Benzoates - therapeutic use
- Cross-Over Studies -
- Double-Blind Method -
- Female -
- Glucose Intolerance - blood Glucose Intolerance - drug therapy Glucose Intolerance - physiopathology
- Humans -
- Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology
- Hypoglycemic Agents - therapeutic use
- Male -
- Middle Aged -
- Prospective Studies -
- Vascular Diseases - drug therapy Vascular Diseases - metabolism Vascular Diseases - physiopathology
- Find related publications in this database (Keywords)
- Impaired glucose tolerance
- Endothelial function
- Hypertension
- Telmisartan