Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Klein, M; Rosen, A; Lahousen, M; Graf, A; Vavra, N; Pakisch, B; Poschauko, J; Beck, A; Kucera, H.
Evaluation of adjuvant therapy after surgery for primary carcinoma of the fallopian tube.
Arch Gynecol Obstet. 1994; 255(1):19-24
Doi: 10.1007/BF02390670
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- Co-Autor*innen der Med Uni Graz
- Lahousen Manfred
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- Abstract:
- OBJECTIVE: To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival. DESIGN: A nationwide retrospective analysis. SETTING: Hanusch-Krankenhaus, Department of Gynaecology, SUBJECTS: 115 patients with histologically proved primary carcinoma of the Fallopian tube: 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment. RESULTS: The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P = 0.62). CONCLUSIONS: Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Carcinoma - drug therapy
- Chemotherapy, Adjuvant - drug therapy
- Cisplatin - administration and dosage
- Combined Modality Therapy - administration and dosage
- Fallopian Tube Neoplasms - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Humans - drug therapy
- Middle Aged - drug therapy
- Neoplasm Staging - drug therapy
- Radiotherapy Dosage - drug therapy
- Retrospective Studies - drug therapy
- Survival Analysis - drug therapy
- Survival Rate - drug therapy
- Find related publications in this database (Keywords)
- Primary Carcinoma of the Fallopian Tube
- Adjuvant Therapy