Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Salmhofer, W; Kawahara, Y; Soyer, HP; Kerl, H; Nishikawa, T; Hashimoto, T.
A subepidermal blistering disease with histopathological features of dermatitis herpetiformis and immunofluorescence characteristics of bullous pemphigoid: a novel subepidermal blistering disease or a variant of bullous pemphigoid?
Br J Dermatol. 1997; 137(4):599-604
Doi: 10.1111/j.1365-2133.1997.tb03794.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Salmhofer Wolfgang
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- A 64-year-old man presented with a bullous eruption which clinically and histopathologically resembled dermatitis herpetiformis. However, direct immunofluorescence analysis showed IgG deposits at the basement membrane zone, indicating a relationship with bullous pemphigoid or epidermolysis bullosa acquisita. Indirect immunofluorescence studies on salt-split skin showed binding of IgG mainly on the dermal side of the blister. Immunoblot analysis revealed a novel 200 kDa dermal antigen that could be associated with a major pathogen in this blistering disease. The histopathological similarity to dermatitis herpetiformis and the immunofluorescence findings indicating bullous pemphigoid or epidermolysis bullosa acquisita seem typical of a distinct subepidermal blistering disease characterized by this 200 kDa antigen. However, the pathogenetic role of autoantibodies against this antigen should be further elucidated before confirming whether this case represents a novel subepidermal blistering disease or a special variant of bullous pemphigoid.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoantigens - analysis
- Basement Membrane - immunology
- Dermatitis Herpetiformis - pathology
- Diagnosis, Differential - pathology
- Fluorescent Antibody Technique - pathology
- Humans - pathology
- Immunoglobulin G - analysis
- Male - analysis
- Middle Aged - analysis
- Pemphigoid, Bullous - classification
- Skin Diseases, Vesiculobullous - immunology