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SHR Neuro Cancer Cardio Lipid Metab Microb

Prenn, C; Heinemann, A; Schuligoi, R; Peskar, BA.
CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.
Pharmacology. 2008; 81(3): 236-240. Doi: 10.1159/000113730
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Leading authors Med Uni Graz

Schuligoi Rufina

Co-authors Med Uni Graz

Heinemann Akos

Peskar Bernhard

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Abstract:

The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD(2) has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonists/antagonists, which type of PGD(2) receptor mediates this inhibitory effect. The DP1 agonist BW245C dose-dependently inhibited the enteropooling effect of 16,16-dimethyl-PGE(2). This inhibition was counteracted by the DP1 antagonist BWA868C. In contrast, the CRTH2 receptor does not seem to be involved in the anti-enteropooling effect of PGD(2), since the selective agonists 13,14-dihydro-15-keto-PGD(2) and 15(R)-15-methyl-PGD(2) were without effect. Therefore, our results suggest that the inhibitory effect of PGD(2) in the small intestine is mediated via activation of the DP1 receptor.

Find related publications in this database (using NLM MeSH Indexing)

16,16-Dimethylprostaglandin E2 - pharmacology

Animals -

Female -

Hydantoins - administration and dosage

Intestinal Secretions - drug effects

Intestine, Small - drug effects

Prostaglandin D2 - analogs and derivatives

Rats -

Rats, Sprague-Dawley -

Receptors, Immunologic - agonists

Receptors, Prostaglandin - agonists

Find related publications in this database (Keywords)

enteropooling

diarrhea

prostaglandins

prostaglandin

D-2 receptors

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