Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Marschall, HU; Wagner, M; Zollner, G; Trauner, M.
Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors.
MOL PHARM. 2007; 4(6): 895-910. Doi: 10.1021/mp060133c
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Co-authors Med Uni Graz

Trauner Michael

Wagner Martin

Zollner Gernot

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Abstract:

Drug-induced liver injury (DILI) is a rare condition. This review presents a clinical update on the incidence and prevalence of DILI, cellular targets and histopathological features of liver injury, and basic diagnostic approaches. At present, with the exception of acetaminophen poisoning where timely administered N-acetylcysteine serves as the antidote, treatment usually is supportive. Since most biotransformation processes in the liver are under the control of nuclear receptors (NR), treatment modalities aiming to stimulate or inhibit NR expression are at present tested in animal models of APAP toxicity or cholestasis. Some NR ligands have also been used in human cholestatic liver disease, but studies on the efficacy in DILI are lacking. This review describes possible future options for the treatment of DILI.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Antidotes - therapeutic use

Cholestasis - drug therapy

Drug-Induced Liver Injury - drug therapy

Humans -

Ligands -

Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - antagonists and inhibitors Receptors, Cytoplasmic and Nuclear - drug effects

Find related publications in this database (Keywords)

nuclear receptors

conjugation

hydroxylation

detoxification

drug-induced liver disease

acetaminophen

cholestasis

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