Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Fickert, P; Moustafa, T; Trauner, M.
Primary sclerosing cholangitis--the arteriosclerosis of the bile duct?
Lipids Health Dis. 2007; 6(2):3-3 Doi: 10.1186/1476-511X-6-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Fickert Peter

Trauner Michael

Co-authors Med Uni Graz

Moustafa Tarek

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Abstract:

Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of unknown aetiology affecting the large bile ducts and characterized by periductal fibrosis and stricture formation, which ultimately result in biliary cirrhosis and liver failure. Arteriosclerosis involves the accumulation of altered lipids and lipoproteins in large arteries; this drives inflammation and fibrosis and ultimately leads to narrowing of the arteries and hypoperfusion of dependent organs and tissues. Knowledge of the causative factors is crucial to the understanding of disease mechanisms and the development of specific treatment. Based on pathogenetic similarities between PSC and arteriosclerosis, we hypothesize that PSC represents "arteriosclerosis of the bile duct" initiated by toxic biliary lipids. This hypothesis is based on common molecular, cellular, and morphological features providing the conceptual framework for a deeper understanding of their pathogenesis. This hypothesis should stimulate translational research to facilitate the search for novel treatment strategies for both diseases.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Arteriosclerosis - classification Arteriosclerosis - physiopathology

Bile Duct Diseases - classification Bile Duct Diseases - physiopathology

Cholangitis, Sclerosing - classification Cholangitis, Sclerosing - physiopathology

Disease Models, Animal -

Endothelial Cells - pathology Endothelial Cells - physiology

Endothelium, Vascular - physiopathology

Humans -

Mice -

Mice, Knockout -

P-Glycoproteins - genetics

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