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Stadlbauer, V; Fickert, P; Lackner, C; Schmerlaib, J; Krisper, P; Trauner, M; Stauber, RE.
Hepatotoxicity of NONI juice: report of two cases.
World J Gastroenterol. 2005; 11(30):4758-4760 Doi: 10.3748/wjg.v11.i30.4758 (- Case Report) [OPEN ACCESS]
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Leading authors Med Uni Graz

Stadlbauer-Köllner Vanessa

Stauber Rudolf

Co-authors Med Uni Graz

Fickert Peter

Krisper Peter

Lackner Karoline

Trauner Michael

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Abstract:

NONI juice (Morinda citrifolia) is an increasingly popular wellness drink claimed to be beneficial for many illnesses. No overt toxicity has been reported to date. We present two cases of novel hepatotoxicity of NONI juice. Causality of liver injury by NONI juice was asses-sed. Routine laboratory tests and transjugular or percutaneous liver biopsy were performed. The first patient underwent successful liver transplantation while the second patient recovered spontaneously after cessation of NONI juice. A 29-year-old man with previous toxic hepatitis associated with small doses of paracetamol developed sub-acute hepatic failure following consumption of 1.5 L NONI juice over 3 wk necessitating urgent liver transplantation. A 62-year-old woman without evidence of previous liver disease developed an episode of self-limited acute hepatitis following consumption of 2 L NONI juice for over 3 mo. The most likely hepatotoxic components of Morinda citrifolia were anthraquinones. Physicians should be aware of potential hepatotoxicity of NONI juice.

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Beverages - toxicity

Drug-Induced Liver Injury - etiology Drug-Induced Liver Injury - pathology

Female -

Humans -

Liver - drug effects Liver - pathology

Liver Transplantation -

Male -

Middle Aged -

Morinda - toxicity

Plant Preparations - toxicity

Find related publications in this database (Keywords)

Herbal hepatotoxicity

Drug-induced hepatitis

NONI juice

Acute liver failure

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