Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Geier, A; Fickert, P; Trauner, M.
Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis.
Nat Clin Pract Gastroenterol Hepatol. 2006; 3(10): 574-585. Doi: 10.1038/ncpgasthep0602
Web of Science PubMed FullText FullText_MUG Google Scholar

 

Leading authors Med Uni Graz

Trauner Michael

Co-authors Med Uni Graz

Fickert Peter

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Cholestasis is a common complication in patients with extrahepatic bacterial infection and sepsis. This article gives a comprehensive overview of the molecular and cellular mechanisms of sepsis-associated cholestasis. Recent advances in the understanding of intrahepatic cholestasis have allowed us to delineate the molecular mechanisms that underlie sepsis-associated cholestasis and to describe their potential clinical and therapeutic applications. The mechanisms and clinical presentation of sepsis-associated liver injury vary according to the severity of the bacterial infection. Proinflammatory cytokines and nitric oxide cause cholestasis by impairing hepatocellular and ductal bile formation. Ischemic liver injury and, rarely, progressive sclerosing cholangitis can also be found in patients with septic shock, or major trauma with systemic inflammatory response syndrome. Treatment is mainly focused on eradication of the underlying infection and managing the sepsis. The use of ursodeoxycholic acid or extracorporeal liver support as treatments for sepsis-associated cholestasis is under investigation, but neither can be recommended in routine clinical practice at present. Patients with progressive sclerosing cholangitis should be considered for orthotopic liver transplantation.

Find related publications in this database (using NLM MeSH Indexing)

Adrenal Cortex Hormones - therapeutic use

Bacterial Infections - complications

Bile - metabolism

Bile Ducts - physiopathology

Cholestasis - drug therapy Cholestasis - etiology Cholestasis - physiopathology

Cytokines - metabolism

Humans -

Liver - physiopathology

Liver Diseases - etiology Liver Diseases - therapy

Liver Transplantation -

Nitric Oxide - metabolism

Sepsis - complications Sepsis - therapy

Ursodeoxycholic Acid - therapeutic use

© Med Uni Graz • Imprint