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SHR Neuro Cancer Cardio Lipid Metab Microb

Murkovic, M; Abuja, PM; Bergmann, AR; Zirngast, A; Adam, U; Winklhofer-Roob, BM; Toplak, H.
Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study.
EUR J CLIN NUTR. 2004; 58: 244-249. Doi: 10.1038/sj.ejcn.1601773 [OPEN ACCESS]
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Co-authors Med Uni Graz

Abuja Peter Michael

Toplak Hermann

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Abstract:

BACKGROUND: In a recent pilot study, the intake of elderberry juice resulted in a significant decrease in serum cholesterol concentrations and an increase in low-density lipoprotein (LDL) stability. This study was designed to verify the preliminary results. OBJECTIVE: We investigated the impact of elderberry juice on cholesterol and triglyceride concentrations as well as antioxidant status in a cohort of young volunteers. DESIGN: Study A: The randomized, placebo-controlled trial for studying the effect of anthocyanes on lipid and antioxidant status, 34 subjects took capsules with 400 mg spray-dried powder containing 10% anthocyanes t.i.d. equivalent to 5 ml elderberry juice for 2 weeks. A subgroup of 14 subjects continued for an additional week to test for resistance to oxidation of LDL. Study B: To investigate the short-term effects on serum lipid concentrations, six subjects took a single dose of 50 ml of elderberry juice (equivalent to 10 capsules) along with a high-fat breakfast. RESULTS: In the placebo-controlled study, there was only a small, statistically not significant change in cholesterol concentrations in the elderberry group (from 199 to 190 mg/dl) compared to the placebo group (from 192 to 196 mg/dl). The resistance to copper-induced oxidation of LDL did not change within 3 weeks. In the single-dose experiment increases in postprandial triglyceride concentrations were not significantly different when the six subjects were investigated with and without elderberry juice. CONCLUSIONS: Elderberry spray-dried extract at a low dose exerts a minor effect on serum lipids and antioxidative capacity. Higher, but nutritionally relevant doses might significantly reduce postprandial serum lipids.

Find related publications in this database (using NLM MeSH Indexing)

Antioxidants - administration and dosage

Ascorbic Acid - blood

Beverages - blood

Cholesterol - blood

Chromatography, High Pressure Liquid - blood

Double-Blind Method - blood

Fasting - blood

Female - blood

Humans - blood

Lipids - blood

Lipoproteins, LDL - blood

Male - blood

Oxidation-Reduction - blood

Postprandial Period - physiology

Sambucus - metabolism

Find related publications in this database (Keywords)

elderberry

anthocyanes

lipids

antioxidants

LDL

oxidation

postprandial hyperlipidemia

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