Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pikija, S; Magdic, J; Liebeskind, DS; Karamyan, A; Bubel, N; McCoy, MR; Sellner, J.
Sigmoid Sinus Characteristics Correlate with Early Clinical and Imaging Surrogates in Anterior Circulation Ischemic Stroke.
Mol Neurobiol. 2017; 54(7): 5583-5589. Doi: 10.1007/s12035-016-0091-0 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz

Pikija Slaven

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Cerebral venous outflow may play a decisive role in acute ischemic stroke. Here, we assessed the relation of cerebral sinus vein characteristics with clinical and imaging surrogates of early outcome in acute ischemic stroke. We evaluated cerebral vein characteristics in 212 patients with the middle cerebral artery (MCA) occlusive stroke confirmed by CT angiography CTA within 6 h from symptom onset. Readout parameters included volume and density of the sigmoid sinus (SS) and density of the superior sagittal sinus (SupSagS). These were correlated with early clinical outcome defined as hospital death (HD), final infarct volume (FIV), and National Institute of Health Stroke Scale (NIHSS) at discharge. We found a correlation for the volume of the right SS and the FIV when the M1 segment of the MCA of either side was occluded (p = 0.002, Rho = 0.206, n = 134). A decrease in SS density was more pronounced in the subgroup with unfavorable outcome (NIHSS > 15 + HD) but only when the left hemisphere was affected (p = 0.026, n = 101). On stepwise logistic regression analysis, adjusted for on-admission NIHSS, age at presentation, and FIV, smaller SS volume was independently associated with lower odds for hospital death (n = 183, OR 0.13, 95 % CI 0.02-0.94, p = 0.043). A larger right SS and a decrease in density increase the risk of unfavorable early clinical and imaging outcome in AIS. This finding of an outflow pattern independent of the stroke site implicates an involvement of the cerebral venous drainage system in the pathophysiology of ischemic stroke.

Find related publications in this database (using NLM MeSH Indexing)

Aged - administration & dosage

Aged, 80 and over - administration & dosage

Brain Ischemia - diagnostic imaging, drug therapy, pathology

Cerebrovascular Circulation - drug effects

Female - administration & dosage

Humans - administration & dosage

Infarction, Middle Cerebral Artery - therapy

Male - administration & dosage

Middle Aged - administration & dosage

Stroke - diagnostic imaging, drug therapy, pathology

Thrombolytic Therapy - methods

Treatment Outcome - administration & dosage

Find related publications in this database (Keywords)

Ischemic stroke

Cerebral veins

Biomarker

Densitometry

Outcome

Computed tomography

© Med Uni Graz • Impressum