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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pikija, S; Magdic, J; Lukic, A; Schreiber, C; Mutzenbach, JS; McCoy, MR; Sellner, J.
Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke.
Int J Mol Sci. 2016; 17(9): Doi: 10.3390/ijms17091382 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Pikija Slaven

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Abstract:

We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Central European stroke centers. The acquisition of non-contrast enhanced CT (NECT) and CT angiography (CTA) within 4.5 h of symptom onset was obligatory. We assessed the site of MCA occlusion as well as density, area, and length of the clot in 150 patients. The Hounsfield unit values for the clot were divided with contralateral MCA segment to yield relative Hounsfield Unit ratio (rHU). The site of the vessel occlusion (M1 vs. M2) and antiplatelet usage, but not stroke etiology, significantly influenced rHU. We found an inverse correlation of rHU with erythrocyte count (p < 0.001). The multivariate analysis revealed that a higher rHU (i.e., clot being more hyperdense) was more likely with the use of antiplatelets (OR 4.24, CI 1.10-16.31, p = 0.036). Erythrocyte (OR 0.18, CI 0.05-0.55, p = 0.003), and thrombocyte counts (OR 0.99, CI 0.98-0.99, p = 0.029) were associated with odds for more hypodense clots (lower rHU). Our study disclosed that antiplatelet therapy impacts the composition of intracranial clots of the anterior circulation.

Find related publications in this database (using NLM MeSH Indexing)

Aged - administration & dosage

Aged, 80 and over - administration & dosage

Blood Platelets - pathology

Erythrocyte Count - administration & dosage

Female - administration & dosage

Humans - administration & dosage

Male - administration & dosage

Multivariate Analysis - administration & dosage

Platelet Aggregation Inhibitors - therapeutic use

Retrospective Studies - administration & dosage

Stroke - drug therapy, pathology

Tomography, X-Ray Computed - administration & dosage

Find related publications in this database (Keywords)

ischemic stroke

hyperdense artery sign

antiplatelets

computed tomography

clot

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