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SHR Neuro Cancer Cardio Lipid Metab Microb

Reisinger, AC; Schneider, N; Koellinger, M; Hatzl, S; Hackl, G; Raggam, R; von, Lewinski, D; Posch, F; Eller, P.
Anticoagulation Monitoring Strategies During Extracorporeal Membrane Oxygenation (ECMO) Therapy - Differences Between Simultaneously Obtained Coagulation Tests: A Retrospective Single-Center Cohort Study.
J Intensive Care Med. 2025; 8850666241313357 Doi: 10.1177/08850666241313357
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Leading authors Med Uni Graz

Eller Philipp

Reisinger Alexander Christian

Schneider Nikolaus

Co-authors Med Uni Graz

Hackl Gerald

Hatzl Stefan

Posch Florian

Raggam Reinhard Bernd

von Lewinski Dirk

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Abstract:

INTRODUCTION: During extracorporeal membrane oxygenation (ECMO) systemic anticoagulation with unfractionated heparin (UFH) is standard-of-care. However, there is uncertainty regarding optimal anticoagulation monitoring strategies. METHODS: We retrospectively investigated venovenous and venoarterial ECMO patients at the medical ICUs at the Medical University of Graz, Austria. We analyzed the correlation and concordance of R-time in thromboelastography (TEG), activated partial thromboplastin time (aPTT), and anti-Xa activity. The proportion within target range, the association of coagulation parameters above or below target range (aPTT 54-72 s; equals 1.5-2× upper limit of normal (ULN), anti-Xa activity 0.2-0.5 U/mL, and R-time in assays without heparinase 675-900 s; equals 1.5-2× ULN) with mortality, bleeding events and thrombotic complications were investigated. RESULTS: We analyzed 671 clusters of simultaneously performed coagulation tests in 85 ECMO cases that fulfilled inclusion criteria. Median age of patients was 57 years and 32% were female. There were poor correlations between the three coagulation tests and the proportion of discordance was 46%. Within the target range were 21% of R-time, 15% of aPTT, and 44% of anti-Xa activity measurements. Singular and multiple bleeding events occurred in 25 and 32 patients, respectively. The most common bleeding locations were catheter and cannula insertion sites followed by pulmonary hemorrhage. In VA-ECMO, anti-Xa activity was associated (OR 1.03 [1.01-1.06], p = 0.005) and correlated with bleeding events (spearman rho 0.49, p = 0.002; point biserial 0.49, p = 0.001). aPTT level below target range was associated with reduced mortality (OR 0.98 [0.97-0.99], p = 0.024). Thrombotic events occurred in six patients with no association of coagulation tests. CONCLUSION: There was a high rate of discordance and poor correlation between aPTT, anti-Xa activity and R-time in TEG in ECMO patients. We found high rates of bleeding events and in VA-ECMO an association with elevated anti-Xa activity levels.

Find related publications in this database (Keywords)

ECMO

viscoelastic

TEG

heparin

extracorporeal

anti-Xa activity

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