Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gressenberger, P; Posch, F; Adelsmayr, G; Nagy, E; Kaufmann-Bühler, AK; Steiner, J; Janisch, M; Reiter, C; Eibisberger, M; Janek, E; Softic, N; Fuchsjäger, M; Gütl, K; Jud, P; Silbernagel, G; Raggam, RB; Brodmann, M; Gary, T; Schmid, J.
Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism.
Sci Rep. 2024; 14(1): 25962
Doi: 10.1038/s41598-024-77669-z
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- Leading authors Med Uni Graz
- Adelsmayr Gabriel
- Gressenberger Paul Georg
- Schmid Johannes
- Co-authors Med Uni Graz
- Brodmann Marianne
- Eibisberger Martin
- Fuchsjäger Michael
- Gary Thomas
- Janek Elmar
- Janisch Michael August Johann
- Jud Philipp
- Kaufmann-Bühler Ann-Katrin
- Kurzmann-Gütl Katharina
- Nagy Eszter
- Posch Florian
- Raggam Reinhard Bernd
- Reiter Clemens
- Silbernagel Günther
- Softic Nina
- Steiner Jakob
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- Abstract:
- Lipoprotein (a) [Lp(a)] is suspected to have antifibrinolytic effects, however, its relevance for the severity of venous thromboembolic events remains unclear. We studied the association of Lp(a) levels with thrombus load in pulmonary embolism (PE). 90 patients (40% female, median age 70 [56-79] years) at our tertiary care hospital with a diagnosis of acute PE, available Lp(a) levels and CT pulmonary angiography (CT-PA) performed between April 2017 and December 2019 were included. All CT-PA scans were reanalyzed and thrombus load was determined via Qanadli CT obstruction index (CTOI) and most proximal thrombus location. Median Lp(a) levels were 11.4 [9.3-29.1] mg/dL, median D-dimer levels were 4.6 [2.1-9.8] mg/L, median CTOI was 23 [8-50], central PE was present in 27 (30%) patients. Lp(a) did not correlate with CTOI (r = 0.02, p = 0.922) and was not associated with thrombus location (p = 0.369). CTOI significantly correlated with D-dimer (r = 0.43, p < 0.001) and right to left ventricular diameter ratio (r=-0.49, p = < 0.001). Our findings showed that Lp(a) is not associated with thrombus burden in PE, which suggests that a relevant effect of Lp(a) on the extent of venous thromboembolism is unlikely.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Pulmonary Embolism - diagnostic imaging, blood
- Female - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Computed Tomography Angiography - methods
- Aged - administration & dosage
- Lipoprotein(a) - blood
- Thrombosis - diagnostic imaging
- Fibrin Fibrinogen Degradation Products - analysis, metabolism
- Acute Disease - administration & dosage
- Retrospective Studies - administration & dosage