Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Klobučar, I; Habisch, H; Klobučar, L; Trbušić, M; Pregartner, G; Berghold, A; Kostner, GM; Scharnagl, H; Madl, T; Frank, S; Degoricija, V.
Sex-Related Differences in the Associations between Adiponectin and Serum Lipoproteins in Healthy Subjects and Patients with Metabolic Syndrome.
Biomedicines. 2024; 12(9): Doi: 10.3390/biomedicines12091972 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Frank Sasa

Co-authors Med Uni Graz

Berghold Andrea

Habisch Hansjörg

Kostner Gerhard

Madl Tobias

Pregartner Gudrun

Scharnagl Hubert

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Abstract:

The strong associations between the serum levels of adiponectin and the lipoprotein subclasses observed in healthy subjects are much weaker in patients with metabolic syndrome (MS). However, the impact of sex on these associations remained unexplored. Therefore, in the present study, we examined associations between adiponectin and the lipoprotein subclasses, analyzed by nuclear magnetic resonance spectroscopy, separately in healthy females and males, as well as in females and males with MS. We observed negative correlations between adiponectin and VLDL, IDL, and small-dense LDL in healthy males, but neither in healthy females nor in females or males with MS. Additionally, adiponectin was positively correlated with some HDL subclasses in healthy males and females with MS, but not in healthy females or males with MS. Adjusting for age and either body mass index, waist circumference, C-reactive protein, or interleukin-6 weakened the associations between adiponectin and VLDL and IDL but not small-dense LDL. The adjustment weakened the associations between adiponectin and HDL in healthy males but not in females with MS. Based on our results, we conclude that sex and the presence of MS are strong determinants of the associations between adiponectin and serum lipoproteins and that the complex regulatory network comprising adiponectin and other molecular players involved in the regulation of lipoprotein metabolism is primarily operative in healthy males and females with MS.

Find related publications in this database (Keywords)

adiponectin

lipoprotein subclasses

metabolic syndrome

sex-related differences

NMR spectroscopy

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