Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Saloň, A; Schmid-Zalaudek, K; Steuber, B; Müller, A; Moser, O; Alnuaimi, S; Fredriksen, PM; Ngwenchi, Nkeh-Chungag, B; Goswami, N.
Acute effects of exercise on macro- and microvasculature in individuals with type 1 diabetes - a secondary outcome analysis.
Front Endocrinol (Lausanne). 2024; 15: 1406930
Doi: 10.3389/fendo.2024.1406930
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- Leading authors Med Uni Graz
- Goswami Nandu
- Salon Adam
- Co-authors Med Uni Graz
- Moser Othmar
- Müller Alexander
- Schmid-Zalaudek Karin
- Steuber Bianca
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- Abstract:
- BACKGROUND: Type 1 diabetes is a chronic autoimmune disease associated with insulin-producing beta cell destruction, declining insulin secretion, and elevated blood glucose. Physical activity improves glycaemic control and cardiovascular health. This study explores acute effects of maximal exhaustion induced by a cardiopulmonary exercise on macro- and microvascular parameters in type 1 diabetes. METHODOLOGY: Twenty-five participants with type 1 diabetes (14 males, 11 females), aged 41.4 ± 11.87 years, BMI 23.7 ± 3.08, completed a repeated-measure study. Measurements pre-, post-, 30- and 60-minutes post-exhaustion involved a maximal incremental cardio-pulmonary exercise test. Macro- and microvascular parameters were assessed using VICORDER® and retinal blood vessel image analysis. Repeated measures ANOVA in SPSS (Version 27.0) analysed data. RESULTS: Post-exercise, heart rate increased (p<.001), and diastolic blood pressure decreased (p=.023). Diabetes duration correlated with pulse wave velocity (r=0.418, p=.047), diastolic blood pressure (r=0.470, p=.023), and central retinal arteriolar equivalent (r=0.492, p=.023). CONCLUSION: In type 1 diabetes, cardiopulmonary exercise-induced exhaustion elevates heart rate and reduces diastolic blood pressure. Future research should explore extended, rigorous physical activity protocols for greater cardiovascular risk reduction.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Diabetes Mellitus, Type 1 - physiopathology
- Male - administration & dosage
- Female - administration & dosage
- Adult - administration & dosage
- Exercise - physiology
- Microvessels - physiopathology
- Middle Aged - administration & dosage
- Heart Rate - physiology
- Blood Pressure - physiology
- Exercise Test - administration & dosage
- Blood Glucose - metabolism
- Find related publications in this database (Keywords)
- diabetes mellitus
- type 1
- exercise
- microcirculation
- haemodynamics
- vascular stiffness