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SHR Neuro Cancer Cardio Lipid Metab Microb

Matsuo, T; Wurster, S; Hoenigl, M; Kontoyiannis, DP.
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology.
Expert Rev Mol Diagn. 2024; 24(9): 841-858. Doi: 10.1080/14737159.2024.2397515
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Hönigl Martin

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Abstract:

INTRODUCTION: Advances in diagnostic technologies, particularly Point-of-Care Diagnostics (POCDs), have revolutionized clinical practice by providing rapid, user-friendly, and affordable testing at or near the patient's location. POCDs have been increasingly introduced in medical mycology and hold promise to improve patient outcomes in a variety of important human fungal diseases. AREAS COVERED: This review focuses on validated POCDs, particularly lateral flow assays (LFAs), for various fungal diseases. Additionally, we discuss emerging innovative techniques such as body fluid analysis, imaging methods, loop-mediated isothermal amplification (LAMP), microfluidic systems, clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostics, and the emerging role of artificial intelligence. EXPERT OPINION: Compact and user-friendly POCDs have been increasingly introduced in medical mycology, and some of these tests (e.g. Cryptococcus and Histoplasma antigen LFAs) have become mainstream diagnostics, while others, such as LFA in invasive aspergillosis show promise to become part of our routine diagnostic armamentarium. POCDs offer immense benefits such as timely and accurate diagnostic results, reduced patient discomfort, and lower healthcare costs and might contribute to antifungal stewardship. Integrated fluidics combined with microtechnology having multiplex capabilities will be pivotal in medical mycology.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Mycoses - diagnosis, microbiology

Molecular Diagnostic Techniques - methods

Point-of-Care Systems - administration & dosage

Point-of-Care Testing - administration & dosage

Mycology - methods

Nucleic Acid Amplification Techniques - methods

Find related publications in this database (Keywords)

Point-of-Care Diagnostics

fungal infections

lateral flow assay

Cryptococcus

Aspergillus

endemic fungal infections

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