Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Sedik, S; Wolfgruber, S; Hoenigl, M; Kriegl, L.
Diagnosing fungal infections in clinical practice: a narrative review.
Expert Rev Anti Infect Ther. 2024; 22(11):935-949 Doi: 10.1080/14787210.2024.2403017
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Hönigl Martin

Kriegl Lisa

Sedik Sarah

Co-authors Med Uni Graz

Wolfgruber Stella

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Abstract:

BACKGROUND: Invasive fungal infections (IFI) present a major medical challenge, with an estimated 6.5 million cases annually, resulting in 3.8 million deaths. Pathogens such as Aspergillus spp. Candida spp. Mucorales spp. Cryptococcus spp. and other fungi species contribute to these infections, posing risks to immunocompromised individuals. Early and accurate diagnosis is crucial for effective treatment and better patient outcomes. AREAS COVERED: This narrative review provides an overview of the current methods and challenges associated with diagnosing fungal diseases, including invasive aspergillosis and invasive candidiasis, as well as rare and endemic fungal infections. Various diagnostic techniques, including microscopy, culture, molecular diagnostics, and serological tests, are reviewed, highlighting their respective advantages and limitations and role in clinical guidelines. To illustrate, the need for improved diagnostic strategies to overcome existing challenges, such as the low sensitivity and specificity of current tests and the time-consuming nature of traditional culture-based methods, is addressed. EXPERT OPINION: Current advancements in fungal infection diagnostics have significant implications for healthcare outcomes. Improved strategies like molecular testing and antigen detection promise early detection of fungal pathogens, enhancing patient management. Challenges include global access to advanced technologies and the need for standardized, user-friendly point-of-care diagnostics to improve diagnosis of fungal infections globally.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Invasive Fungal Infections - diagnosis, microbiology

Sensitivity and Specificity - administration & dosage

Molecular Diagnostic Techniques - administration & dosage

Immunocompromised Host - administration & dosage

Practice Guidelines as Topic - administration & dosage

Candidiasis, Invasive - diagnosis, drug therapy, microbiology

Mycoses - diagnosis, microbiology

Find related publications in this database (Keywords)

Diagnostic gold standard

invasive fungal infections

mold infections

yeast infections

microscopy

culture

PCR

antigen biomarkers

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