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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Amor, M; Diaz, M; Bianco, V; Svecla, M; Schwarz, B; Rainer, S; Pirchheim, A; Schooltink, L; Mukherjee, S; Grabner, GF; Beretta, G; Lamina, C; Norata, GD; Hackl, H; Kratky, D.
Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model.
Cardiovasc Diabetol. 2024; 23(1): 298
Doi: 10.1186/s12933-024-02397-7
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- Leading authors Med Uni Graz
- Amor Melina
- Diaz Malena
- Kratky Dagmar
- Co-authors Med Uni Graz
- Bianco Valentina
- Grabner Gernot
- Mukherjee Suravi
- Pirchheim Anita
- Rainer Silvia
- Schooltink Laszlo
- Schwarz Birgit
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- Abstract:
- BACKGROUND: Activation of brown adipose tissue (BAT) has gained attention due to its ability to dissipate energy and counteract cardiometabolic diseases (CMDs). METHODS: This study investigated the consequences of cold exposure on the BAT and liver proteomes of an established CMD mouse model based on LDL receptor-deficient (LdlrKO) mice fed a high-fat, high-sucrose, high-cholesterol diet for 16 weeks. We analyzed energy metabolism in vivo and performed untargeted proteomics on BAT and liver of LdlrKO mice maintained at 22 °C or 5 °C for 7 days. RESULTS: We identified several dysregulated pathways, miRNAs, and transcription factors in BAT and liver of cold-exposed Ldlrko mice that have not been previously described in this context. Networks of regulatory interactions based on shared downstream targets and analysis of ligand-receptor pairs identified fibrinogen alpha chain (FGA) and fibronectin 1 (FN1) as potential crosstalk factors between BAT and liver in response to cold exposure. Importantly, genetic variations in the genes encoding FGA and FN1 have been associated with cardiometabolic-related phenotypes and traits in humans. DISCUSSION: This study describes the key factors, pathways, and regulatory networks involved in the crosstalk between BAT and the liver in a cold-exposed CMD mouse model. These findings may provide a basis for future studies aimed at testing whether molecular mediators, as well as regulatory and signaling mechanisms involved in tissue adaption upon cold exposure, could represent a target in cardiometabolic disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Adipose Tissue, Brown - metabolism
- Liver - metabolism
- Disease Models, Animal - administration & dosage
- Mice, Knockout - administration & dosage
- Cold Temperature - administration & dosage
- Gene Regulatory Networks - administration & dosage
- Energy Metabolism - genetics
- Proteomics - administration & dosage
- Receptors, LDL - genetics, metabolism, deficiency
- Signal Transduction - administration & dosage
- Male - administration & dosage
- Fibrinogen - metabolism, genetics
- Mice, Inbred C57BL - administration & dosage
- MicroRNAs - metabolism, genetics
- Fibronectins - metabolism, genetics
- Transcription Factors - genetics, metabolism
- Mice - administration & dosage
- Gene Expression Regulation - administration & dosage
- Protein Interaction Maps - administration & dosage
- Find related publications in this database (Keywords)
- Brown adipose tissue
- Liver
- Cardiometabolic diseases
- Cold exposure
- Ldlr-deficient mice
- Untargeted proteomics