Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Sattler, S; Brandl, K; Eller, K; Rainer, PR.
Is ischemic heart failure also an auto- immune disease?
J KARDIOL. 2024; 31(7-8):
Web of Science

 

Leading authors Med Uni Graz

Sattler Susanne

Co-authors Med Uni Graz

Brandl Katharina

Eller Kathrin

Rainer Peter

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Abstract:

The important role of inflammation in heart failure is now undisputed. However, the adaptive immune system also contributes to cardiac immunopathology. Here, we discuss the contribution of autoimmune mechanisms in the development of heart failure, especially after myocardial infarction. We describe the parallels between heart failure and classical autoimmune diseases and test the applicability of Witebskys' postulates to define auto- immunity. Due to the presence of organ damage, lymphadenopathy and auto-antibodies, heart failure shows the classic clinical features of an established autoimmune disease. In addition, with the presence of auto-antibodies, experimental reproducibility in the animal model with immunopathological lesions comparable to the disease in humans, and the transferability of the disease to healthy recipients by immune cells, the Witebsky postulates for the definition of an autoimmune disease are also fulfilled. Stronger interdisciplinary cooperation between cardiology and immunology should therefore be promoted to better understand fundamental immunological mechanisms in heart failure and to develop personalized therapeutic approaches.

Find related publications in this database (Keywords)

heart failure

autoimmunity

inflam mation

myocarditis

auto-antibodies

myocardial infarction

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