Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Stadler, JT; Bärnthaler, T; Borenich, A; Emrich, IE; Habisch, H; Rani, A; Holzer, M; Madl, T; Heine, GH; Marsche, G.
Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD.
J Lipid Res. 2024; 65(9):100624
Doi: 10.1016/j.jlr.2024.100624
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- Leading authors Med Uni Graz
- Marsche Gunther
- Stadler Julia
- Co-authors Med Uni Graz
- Bärnthaler Thomas
- Borenich Andrea
- Habisch Hansjörg
- Holzer Michael
- Madl Tobias
- RANI Alankrita
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- Abstract:
- Chronic kidney disease (CKD) is often associated with decreased activity of lecithin-cholesterol acyltransferase (LCAT), an enzyme essential for HDL maturation. This reduction in LCAT activity may potentially contribute to an increased risk of cardiovascular mortality in patients with CKD. The objective of this study was to investigate the association between LCAT activity in patients with CKD and the risk of adverse outcomes. We measured serum LCAT activity and characterized lipoprotein profiles using nuclear magnetic resonance spectroscopy in 453 non-dialysis CKD patients from the CARE FOR HOMe study. LCAT activity correlated directly with smaller HDL particle size, a type of HDL potentially linked to greater cardiovascular protection. Over a mean follow-up of 5.0 ± 2.2 years, baseline LCAT activity was inversely associated with risk of death (standardized HR 0.62, 95% CI 0.50-0.76; P < 0.001) and acute decompensated heart failure (ADHF) (standardized HR 0.67, 95% CI 0.52-0.85; P = 0.001). These associations remained significant even after adjusting for other risk factors. Interestingly, LCAT activity was not associated with the incidence of atherosclerotic cardiovascular events or kidney function decline during the follow-up. To conclude, our findings demonstrate that low LCAT activity is independently associated with all-cause mortality and ADHF in patients with CKD, and is directly linked to smaller, potentially more protective HDL subclasses.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Phosphatidylcholine-Sterol O-Acyltransferase - blood
- Male - administration & dosage
- Female - administration & dosage
- Heart Failure - mortality, blood
- Renal Insufficiency, Chronic - blood, mortality, complications
- Aged - administration & dosage
- Middle Aged - administration & dosage
- Acute Disease - administration & dosage
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- LCAT
- kidney
- lipoproteins
- atherosclerosis
- CVD
- cholesterol/metabolism
- chronic kidney disease
- chronic kidney disease
- survival
- HDL