Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Reiter, C; Puseljic, M; Fuchsjäger, M; Schmid, J.
Estimating synthetic hematocrit and extracellular volume from native blood pool T1 times at 3 Tesla CMR: Derivation of a conversion equation, accuracy and comparison with published formulas.
Eur J Radiol. 2024; 178:111659 Doi: 10.1016/j.ejrad.2024.111659
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Puseljic Marijan

Reiter Clemens

Schmid Johannes

Co-authors Med Uni Graz

Fuchsjäger Michael

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

PURPOSE: Calculation of extracellular volume fraction (ECV), a marker of myocardial fibrosis in cardiac magnetic resonance imaging (CMR), requires hematocrit (Hct). We aimed to correlate Hct levels with native blood T1 times, to derive a formula for estimating synthetic Hct (Hct_syn) and synthetic ECV (ECV_syn), to assess accuracy of ECV_syn and to compare our model with published formulas. METHOD: In this retrospective study, a cohort of 250 CMR scans with T1 mapping (3T, MOLLI 5(3)3, endsystolic aquisition), was divided into a derivation and validation cohort. Native T1 times of the left ventricular blood pool (T1_native,midLV) were correlated with Hct levels from blood sampling within 24 h (Hct_24h) and a formula for calculation of Hct_syn was derived by linear regression. RESULTS: In the derivation cohort (n = 167), Hct_24h showed a good association with T1_native,midLV (r = -0.711, p < 0.001). The resulting regression equation was Hctsyn = 1/T1_native,midLV * 1355.52-0.310. In the validation cohort (n = 83), Hct_syn and Hct_24h showed good correlation (r = 0.726, p < 0.001), while ECV_syn, and ECV_24h demonstrated excellent correlation (r = 0.940, p < 0.001). ECV_syn had a minimal bias of 0.28 % and the misclassification rate (8.8 %) was comparable to the variability introduced by repeated Hct measurements (misclassification in 7.5 %). Applying published formulas in our cohort resulted in incorrect classification in up to 60 %. CONCLUSION: We provide a formula for estimating Hct_syn from native blood T1 on a 3T scanner. The measurement error of ECV_syn is low and comparable to the error due to retest variability of conventional Hct. Scanner- and sequence-specific formulas should be used.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Hematocrit - administration & dosage

Male - administration & dosage

Female - administration & dosage

Middle Aged - administration & dosage

Retrospective Studies - administration & dosage

Reproducibility of Results - administration & dosage

Magnetic Resonance Imaging - methods

Adult - administration & dosage

Aged - administration & dosage

Image Interpretation, Computer-Assisted - methods

Sensitivity and Specificity - administration & dosage

Algorithms - administration & dosage

Find related publications in this database (Keywords)

Synthetic ECV

Cardiac magnetic resonance imaging

Hematocrit

Extracellular volume

T1 mapping

© Med Uni Graz • Imprint