Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Rani, A; Stadler, JT; Marsche, G.
HDL-based therapeutics: A promising frontier in combating viral and bacterial infections.
Pharmacol Ther. 2024; 260:108684 Doi: 10.1016/j.pharmthera.2024.108684
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Marsche Gunther

RANI Alankrita

Co-authors Med Uni Graz

Stadler Julia

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Abstract:

Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been consistently associated with increased susceptibility to infection and its serious consequences. This has been attributed to the critical role of HDL in maintaining cellular lipid homeostasis, which is essential for the proper functioning of immune and structural cells. HDL, a multifunctional particle, exerts pleiotropic effects in host defense against pathogens. It functions as a natural nanoparticle, capable of sequestering and neutralizing potentially harmful substances like bacterial lipopolysaccharides. HDL possesses antiviral activity, preventing viruses from entering or fusing with host cells, thereby halting their replication cycle. Understanding the complex relationship between HDL and the immune system may reveal innovative targets for developing new treatments to combat infectious diseases and improve patient outcomes. This review aims to emphasize the role of HDL in influencing the course of bacterial and viral infections and its and its therapeutic potential.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Virus Diseases - drug therapy, immunology

Bacterial Infections - drug therapy

Animals - administration & dosage

Lipoproteins, HDL - metabolism

Antiviral Agents - therapeutic use, pharmacology

Find related publications in this database (Keywords)

HDL

Reconstituted HDL

Synthetic HDL

sepsis

COVID-19

HCV

In fluenza

HIV

Antiviral

Virus

In flammation

Apolipoprotein

HDL mimetics

Immunomodulatory

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