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SHR Neuro Cancer Cardio Lipid Metab Microb

Eigenfeld, M; Lupp, KFM; Schwaminger, SP.
Role of Natural Binding Proteins in Therapy and Diagnostics.
Life (Basel). 2024; 14(5): Doi: 10.3390/life14050630 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Eigenfeld Marco

Schwaminger Sebastian

Co-authors Med Uni Graz

Lupp Kilian

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Abstract:

This review systematically investigates the critical role of natural binding proteins (NBPs), encompassing DNA-, RNA-, carbohydrate-, fatty acid-, and chitin-binding proteins, in the realms of oncology and diagnostics. In an era where cancer continues to pose significant challenges to healthcare systems worldwide, the innovative exploration of NBPs offers a promising frontier for advancing both the diagnostic accuracy and therapeutic efficacy of cancer management strategies. This manuscript provides an in-depth examination of the unique mechanisms by which NBPs interact with specific molecular targets, highlighting their potential to revolutionize cancer diagnostics and therapy. Furthermore, it discusses the burgeoning research on aptamers, demonstrating their utility as 'nucleic acid antibodies' for targeted therapy and precision diagnostics. Despite the promising applications of NBPs and aptamers in enhancing early cancer detection and developing personalized treatment protocols, this review identifies a critical knowledge gap: the need for comprehensive studies to understand the diverse functionalities and therapeutic potentials of NBPs across different cancer types and diagnostic scenarios. By bridging this gap, this manuscript underscores the importance of NBPs and aptamers in paving the way for next-generation diagnostics and targeted cancer treatments.

Find related publications in this database (Keywords)

binding proteins

nanoparticles

binding domains

personalized medicine

drug delivery

targeted delivery

diagnostics

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