Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Xu, R; Vujić, N; Bianco, V; Reinisch, I; Kratky, D; Krstic, J; Prokesch, A.
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases.
Trends Endocrinol Metab. 2024; Doi: 10.1016/j.tem.2024.04.009
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Prokesch Andreas

Xu Ruonan

Co-authors Med Uni Graz

Bianco Valentina

Kratky Dagmar

Krstic Jelena

Reinisch Isabel Nadine

Vujic Nemanja

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Abstract:

Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity identified in various metabolic derangements. During disease development, they locate to atherosclerotic plaques, adipose tissue (AT) of individuals with obesity, liver lesions in steatosis and steatohepatitis, and the intestinal lamina propria. LAMs can also emerge in the metabolically demanding microenvironment of certain tumors. In this review, we discuss major questions regarding LAM recruitment, differentiation, and self-renewal, and, ultimately, their acute and chronic functional impact on the development of metabolic diseases. Further studies need to clarify whether and under which circumstances LAMs drive disease progression or resolution and how their phenotype can be modulated to ameliorate metabolic disorders.

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