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SHR Neuro Cancer Cardio Lipid Metab Microb

Zittermann, A; Zelzer, S; Herrmann, M; Gummert, JF; Kleber, M; Trummer, C; Theiler-Schwetz, V; Keppel, MH; Maerz, W; Pilz, S.
Determinants of circulating calcitriol in cardiovascular disease.
J Steroid Biochem Mol Biol. 2024; 241:106528 Doi: 10.1016/j.jsbmb.2024.106528
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Co-authors Med Uni Graz

Herrmann Markus

Keppel Martin Helmut

März Winfried

Pilz Stefan

Theiler-Schwetz Verena

Trummer Christian

Zelzer Sieglinde

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Abstract:

Circulating calcitriol may contribute to the risk of cardiovascular disease (CVD), but its regulation in patients with CVD is poorly characterized. We therefore aimed to assess determinants of circulating calcitriol in these patients. We analyzed 2183 independent samples from a large cohort of patients scheduled for coronary angiography and 1727 independent samples from different other cohorts from patients with a wide range of CVDs, including heart transplant candidates, to quantify the association of different parameters with circulating calcitriol. We performed univariable and multivariable linear regression analyses using the mathematical function that fitted best with circulating calcitriol. In the multivariable analysis of the large single cohort, nine parameters remained significant, explaining 30.0 % (32.4 % after exclusion of 22 potential outliers) of the variation in circulating calcitriol (r=0.548). Log-transformed 25-hydroxyvitamin D [25(OH)D] and log-transformed glomerular filtration rate were the strongest predictors, explaining 17.6 % and 6.6 %, respectively, of the variation in calcitriol. In the analysis of the combined other cohorts, including heart transplant candidates, the multivariable model explained a total of 42.6 % (46.1 % after exclusion of 21 potential outliers) of the variation in calcitriol (r=0.653) with log-transformed fibroblast growth factor-23 and log-transformed 25(OH)D explaining 29.0 % and 6.2 %, respectively. Circulating 25(OH)D was positively and FGF-23 inversely associated with circulating calcitriol. Although significant, PTH was only a weak predictor of calcitriol in both analyses (<2.5 %). In patients with CVD, FGF-23 and 25(OH)D are important independent determinants of circulating calcitriol. The relative importance of these two parameters may vary according to CVD severity. Future studies should focus on the clinical importance of regulating circulating calcitriol by different parameters.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Calcitriol - blood

Cardiovascular Diseases - blood

Male - administration & dosage

Female - administration & dosage

Middle Aged - administration & dosage

Fibroblast Growth Factor-23 - blood

Aged - administration & dosage

Vitamin D - blood, analogs & derivatives

Glomerular Filtration Rate - administration & dosage

Fibroblast Growth Factors - blood

Cohort Studies - administration & dosage

Find related publications in this database (Keywords)

Calcitriol

Fibroblast growth factor-23

25-hydroxyvitamin D

Cardiovascular disease

Regulation

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