Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Herz, D; Karl, S; Weiß, J; Zimmermann, P; Haupt, S; Zimmer, RT; Schierbauer, J; Wachsmuth, NB; Erlmann, MP; Niedrist, T; Khoramipour, K; Voit, T; Rilstone, S; Sourij, H; Moser, O.
Effects of Different Types of Intermittent Fasting Interventions on Metabolic Health in Healthy Individuals (EDIF): A Randomised Trial with a Controlled-Run in Phase.
Nutrients. 2024; 16(8): 1114 Doi: 10.3390/nu16081114 [OPEN ACCESS]
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Leading authors Med Uni Graz

Moser Othmar

Co-authors Med Uni Graz

Niedrist Tobias Josef

Sourij Harald

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Abstract:

The effects of intermittent fasting (IF) on health promotion in the healthy population remain controversial. Therefore, our study aimed to analyse the efficacy and feasibility of different IF protocols and evaluated the effects within a cohort with a controlled-run in phase on the body mass index (BMI) as the primary outcome, the body composition, and metabolic and haematological markers in healthy participants. A total of 25 individuals were randomised into three fasting groups: 16/8 fasting (n = 11), 20/4 fasting (n = 6), and alternate-day fasting (ADF, n = 8). Assessments were conducted at baseline (visit 1), after a four-week controlled-run in phase (visit 2), and after eight weeks of fasting (visit 3). Both the BMI (p = 0.01) and bodyweight (p = 0.01) were significantly reduced in the ADF group, which was not seen in the 16/8 and 20/4 groups (p > 0.05). Adherence was different but not statistically among the groups (16/8: 84.5 ± 23.0%; 20/4: 92.7 ± 9.5%; and ADF: 78.1 ± 33.5%, p = 0.57). Based on our obtained results, the data suggest that some fasting interventions might be promising for metabolic health. However, adherence to the specific fasting protocols remains challenging even for the healthy population.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Fasting - administration & dosage

Male - administration & dosage

Female - administration & dosage

Adult - administration & dosage

Body Mass Index - administration & dosage

Body Composition - administration & dosage

Middle Aged - administration & dosage

Young Adult - administration & dosage

Healthy Volunteers - administration & dosage

Body Weight - administration & dosage

Biomarkers - blood

Blood Glucose - metabolism

Intermittent Fasting - administration & dosage

Find related publications in this database (Keywords)

time-restricted feeding

anthropometry

weight loss

metabolism

body mass index

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