Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Marcelino, VR; Welsh, C; Diener, C; Gulliver, EL; Rutten, EL; Young, RB; Giles, EM; Gibbons, SM; Greening, C; Forster, SC.
Disease-specific loss of microbial cross-feeding interactions in the human gut.
Nat Commun. 2023; 14(1): 6546 Doi: 10.1038/s41467-023-42112-w [OPEN ACCESS]
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Co-authors Med Uni Graz

Diener Christian

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Abstract:

Many gut microorganisms critical to human health rely on nutrients produced by each other for survival; however, these cross-feeding interactions are still challenging to quantify and remain poorly characterized. Here, we introduce a Metabolite Exchange Score (MES) to quantify those interactions. Using metabolic models of prokaryotic metagenome-assembled genomes from over 1600 individuals, MES allows us to identify and rank metabolic interactions that are significantly affected by a loss of cross-feeding partners in 10 out of 11 diseases. When applied to a Crohn's disease case-control study, our approach identifies a lack of species with the ability to consume hydrogen sulfide as the main distinguishing microbiome feature of disease. We propose that our conceptual framework will help prioritize in-depth analyses, experiments and clinical targets, and that targeting the restoration of microbial cross-feeding interactions is a promising mechanism-informed strategy to reconstruct a healthy gut ecosystem.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

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