Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kneihsl, M; Gattringer, T; Hofer, E; Rainer, PP; Ranner, G; Fandler-Höfler, S; Haidegger, M; Perl, S; Enzinger, C; Schmidt, R.
Cerebral white matter hyperintensities indicate severity and progression of coronary artery calcification.
Sci Rep. 2024; 14(1): 4664
Doi: 10.1038/s41598-024-55305-0
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- Leading authors Med Uni Graz
- Gattringer Thomas
- Kneihsl Markus
- Co-authors Med Uni Graz
- Enzinger Christian
- Fandler-Höfler Simon
- Haidegger Melanie
- Hofer Edith
- Perl Sabine
- Rainer Peter
- Schmidt Reinhold
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- Abstract:
- Cerebral white matter hyperintensities (WMH) have been associated with subclinical atherosclerosis including coronary artery calcification (CAC). However, previous studies on this association are limited by only cross-sectional analysis. We aimed to explore the relationship between WMH and CAC in elderly individuals both cross-sectionally and longitudinally. The study population consisted of elderly stroke- and dementia-free participants from the community-based Austrian Stroke Prevention Family Study (ASPFS). WMH volume and CAC levels (via Agatston score) were analyzed at baseline and after a 6-year follow-up period. Of 324 study participants (median age: 68 years), 115 underwent follow-up. Baseline WMH volume (median: 4.1 cm3) positively correlated with baseline CAC levels in multivariable analysis correcting for common vascular risk factors (p = 0.010). While baseline CAC levels were not predictive for WMH progression (p = 0.447), baseline WMH volume was associated CAC progression (median Agatston score progression: 27) in multivariable analysis (ß = 66.3 ± 22.3 [per cm3], p = 0.004). Ten of 11 participants (91%) with severe WMH (Fazekas Scale: 3) at baseline showed significant CAC progression > 100 during follow-up. In this community-based cohort of elderly individuals, WMH were associated with CAC and predictive of its progression over a 6-year follow-up. Screening for coronary artery disease might be considered in people with more severe WMH.
- Find related publications in this database (Keywords)
- Coronary artery calcification
- White matter hyperintensities
- Cerebral small vessel disease
- Aging