Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Yadav, S; Waldeck-Weiermair, M; Spyropoulos, F; Bronson, R; Pandey, AK; Das, AA; Sisti, AC; Covington, TA; Thulabandu, V; Caplan, S; Chutkow, W; Steinhorn, B; Michel, T.
Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines.
Nat Commun. 2023; 14(1): 3094 Doi: 10.1038/s41467-023-38961-0 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Waldeck-Weiermair Markus

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Oxidative stress is associated with cardiovascular and neurodegenerative diseases. Here we report studies of neurovascular oxidative stress in chemogenetic transgenic mouse lines expressing yeast D-amino acid oxidase (DAAO) in neurons and vascular endothelium. When these transgenic mice are fed D-amino acids, DAAO generates hydrogen peroxide in target tissues. DAAO-TG^Cdh5 transgenic mice express DAAO under control of the putatively endothelial-specific Cdh5 promoter. When we provide these mice with D-alanine, they rapidly develop sensory ataxia caused by oxidative stress and mitochondrial dysfunction in neurons within dorsal root ganglia and nodose ganglia innervating the heart. DAAO-TG^Cdh5 mice also develop cardiac hypertrophy after chronic chemogenetic oxidative stress. This combination of ataxia, mitochondrial dysfunction, and cardiac hypertrophy is similar to findings in patients with Friedreich's ataxia. Our observations indicate that neurovascular oxidative stress is sufficient to cause sensory ataxia and cardiac hypertrophy. Studies of DAAO-TG^Cdh5 mice could provide mechanistic insights into Friedreich's ataxia.

Find related publications in this database (using NLM MeSH Indexing)

Mice - administration & dosage

Animals - administration & dosage

Mice, Transgenic - administration & dosage

Friedreich Ataxia - administration & dosage

Cardiomegaly - administration & dosage

Oxidative Stress - administration & dosage

Ataxia - complications

© Med Uni Graz • Imprint