Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Ennis, D; Shmorak, S; Jantscher-Krenn, E; Yassour, M.
Longitudinal quantification of Bifidobacterium longum subsp. infantis reveals late colonization in the infant gut independent of maternal milk HMO composition.
Nat Commun. 2024; 15(1): 894 Doi: 10.1038/s41467-024-45209-y [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Jantscher-Krenn Evelyn

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Breast milk contains human milk oligosaccharides (HMOs) that cannot be digested by infants, yet nourish their developing gut microbiome. While Bifidobacterium are the best-known utilizers of individual HMOs, a longitudinal study examining the evolving microbial community at high-resolution coupled with mothers' milk HMO composition is lacking. Here, we developed a high-throughput method to quantify Bifidobacterium longum subsp. infantis (BL. infantis), a proficient HMO-utilizer, and applied it to a longitudinal cohort consisting of 21 mother-infant dyads. We observed substantial changes in the infant gut microbiome over the course of several months, while the HMO composition in mothers' milk remained relatively stable. Although Bifidobacterium species significantly influenced sample variation, no specific HMOs correlated with Bifidobacterium species abundance. Surprisingly, we found that BL. infantis colonization began late in the breastfeeding period both in our cohort and in other geographic locations, highlighting the importance of focusing on BL. infantis dynamics in the infant gut.

Find related publications in this database (using NLM MeSH Indexing)

Infant - administration & dosage

Female - administration & dosage

Humans - administration & dosage

Health Maintenance Organizations - administration & dosage

Longitudinal Studies - administration & dosage

Milk, Human - administration & dosage

Bifidobacterium - administration & dosage

Oligosaccharides - administration & dosage

Bifidobacterium longum - administration & dosage

© Med Uni Graz • Imprint