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SHR Neuro Cancer Cardio Lipid Metab Microb

Spicher, MT; Schwaminger, SP; von der Haar-Leistl, D; Fellenberg, E; Berensmeier, S.
Process development for pilot-scale spray drying of ultrasmall iron (oxyhydr)oxide nanoparticles
POWDER TECHNOL. 2024; 433: 119186 Doi: 10.1016/j.powtec.2023.119186
Web of Science FullText FullText_MUG

 

Co-authors Med Uni Graz

Schwaminger Sebastian

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Abstract:

In manufacturing iron (oxyhydr)oxide nanoparticles, drying is often necessary to increase stability or to enable granulation and tableting. Lyophilization is a simple drying method, although it is characterized by high energy consumption and high cost. This study aims to demonstrate that spray drying is a suitable alternative for preparing iron (oxyhydr)oxide nanoparticles. A Design of Experiment approach was used varying the inlet air temperature, feed flow rate, and feed concentration. Especially a low feed flow rate was beneficial for low residual moisture (< 7%) and high yield (> 80%). The process was subsequently transferred to pilot scale at a feed flow rate of 2.3 kg/h. The nanomaterial had comparable properties and efficacy to the freeze-dried product. However, about 15% lower yield and 35% lower energy consumption were found for spray drying the nanoparticles. This study shows that spray drying is a suitable alternative to freeze drying for iron (oxyhydr)oxide nanoparticles.

Find related publications in this database (Keywords)

Ferrihydrite

Freeze-drying

Design of experiments

DoE

Lyophilization

Spry-drying

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