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SHR Neuro Cancer Cardio Lipid Metab Microb

Zach, DK; Schwegel, N; Santner, V; Winkelbauer, L; Hoeller, V; Kolesnik, E; Gollmer, J; Seggewiss, H; Batzner, A; Perl, S; Wallner, M; Reiter, U; Rainer, PP; Zirlik, A; Ablasser, K; Verheyen, N.
Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy.
Int J Cardiol. 2024; 399:131661 Doi: 10.1016/j.ijcard.2023.131661
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Zach David

Co-authors Med Uni Graz

Ablasser Klemens

Gollmer Johannes

Höller Viktoria

Kolesnik Ewald

Perl Sabine

Rainer Peter

Reiter Ursula

Santner Viktoria

Schwegel Nora

Verheyen Nicolas Dominik

Wallner Markus

Zirlik Andreas

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Abstract:

BACKGROUND: Arterial hypertension (HTN) is associated with excess mortality in hypertrophic cardiomyopathy (HCM), but underlying mechanisms are largely elusive. The objective of this study was to investigate the association between HTN and markers of left ventricular (LV) dysfunction and low-grade systemic inflammation in a HCM cohort. METHODS: This was a single-center cross-sectional case-control study comparing echocardiographic and plasma-derived indices of LV dysfunction and low-grade systemic inflammation between 30 adult patients with HCM and HTN (HTN+) and 30 sex- and age-matched HCM patients without HTN (HTN-). Echocardiographic measures were assessed using post-processing analyses by blinded investigators. RESULTS: Mean age of the study population was 55.1 ± 10.4 years, 30% were women. Echocardiographic measures of systolic and diastolic dysfunction, including speckle-tracking derived parameters, did not differ between HTN+ and HTN-. Moreover, levels of N-terminal pro B-type natriuretic peptide were balanced between cases and controls. Compared with HTN-, HTN+ patients exhibited a higher white blood cell count [8.1 ± 1.8 10⁹/l vs. 6.4 ± 1.6 10⁹/l; p < 0.001] as well as higher plasma levels of interleukin-6 [2.8 pg/ml (2.0, 5.4) vs. 2.1 pg/ml (1.5, 3.4); p = 0.008] and high-sensitivity C-reactive protein [2.6 mg/l (1.4, 6.5) vs. 1.1 mg/l (0.9, 2.4); p = 0.004]. CONCLUSION: This study demonstrates that HTN is associated with indices of low-grade systemic inflammation among HCM patients. Moreover, this analysis indicates that the adverse impact of HTN in HCM patients is a consequence of systemic effects rather than alterations of cardiac function, as measures of LV systolic and diastolic dysfunction did not differ between HTN+ and HTN-.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Humans - administration & dosage

Female - administration & dosage

Middle Aged - administration & dosage

Aged - administration & dosage

Male - administration & dosage

Case-Control Studies - administration & dosage

Cross-Sectional Studies - administration & dosage

Cardiomyopathy, Hypertrophic - complications, diagnostic imaging

Ventricular Dysfunction, Left - administration & dosage

Hypertension - administration & dosage

Inflammation - diagnostic imaging, complications

Hypertrophy, Left Ventricular - administration & dosage

Find related publications in this database (Keywords)

Hypertrophic cardiomyopathy

Hypertension

Inflammation

Left ventricular dysfunction

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