Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Hoffmann, WG; Chen, YQ; Schwartz, CS; Barber, JL; Dev, PK; Reasons, RJ; Miranda, Maravi, JS; Armstrong, B; Gerszten, RE; Silbernagel, G; Konrad, RJ; Bouchard, C; Sarzynski, MA.
Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits.
J Lipid Res. 2024; 65(2):100495 Doi: 10.1016/j.jlr.2023.100495 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Silbernagel Günther

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Abstract:

Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown. We characterized ANGPTL3/8 and ANGPTL4/8 and their relationship with in vivo measurements of lipase activities and cardiometabolic traits before and after a 5-month endurance exercise training intervention in 642 adults from the HERITAGE (HEalth, RIsk factors, exercise Training And GEnetics) Family Study. At baseline, higher levels of both ANGPTL3/8 and ANGPTL4/8 were associated with a worse lipid, lipoprotein, and cardiometabolic profile, with only ANGPTL3/8 associated with postheparin LPL and HL activities. ANGPTL3/8 significantly decreased with exercise training, which corresponded with increases in LPL activity and decreases in HL activity, plasma triglycerides, apoB, visceral fat, and fasting insulin (all P < 5.1 × 10^-4). Exercise-induced changes in ANGPTL4/8 were directly correlated to concomitant changes in total cholesterol, LDL-C, apoB, and HDL-triglycerides and inversely related to change in insulin sensitivity index (all P < 7.0 × 10^-4). In conclusion, exercise-induced decreases in ANGPTL3/8 and ANGPTL4/8 were related to concomitant improvements in lipase activity, lipid profile, and cardiometabolic risk factors. These findings reveal the ANGPTL3-4-8 model as a potential molecular mechanism contributing to adaptations in lipid metabolism in response to exercise training.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Humans - administration & dosage

Angiopoietin-like Proteins - metabolism

Angiopoietin-Like Protein 3 - administration & dosage

Triglycerides - metabolism

Lipase - administration & dosage

Exercise - administration & dosage

Cardiovascular Diseases - administration & dosage

Apolipoproteins B - administration & dosage

Lipoprotein Lipase - genetics

Angiopoietin-Like Protein 4 - administration & dosage

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