Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Schranz, A; Sternad, C; Aziz, F; Wagner, D; Kornprat, P; Sucher, R; Jost, PJ; Wölfler, A; Pieber, TR; Sourij, H; Riedl, JM; Aberer, F.
Incidence of Diabetes Mellitus and Its Impact on Outcomes in Patients Undergoing Surgical Pancreatectomy for Non-Malignant and Malignant Pancreatobiliary Diseases-A Retrospective Analysis.
J Clin Med. 2023; 12(24): Doi: 10.3390/jcm12247532 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Sourij Harald

Co-authors Med Uni Graz

Aberer Felix

Aziz Faisal

Jost Philipp

Kornprat Peter

Pieber Thomas

Riedl Jakob

Sternad Christoph Peter

Sucher Robert

Wagner Doris

Wölfler Albert

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Abstract:

Diabetes mellitus (DM) is a prominent risk factor for malignant and non-malignant pancreatic diseases. Furthermore, the presence of DM predicts an unfavourable outcome in people with pancreatic cancer. This retrospective observational study investigated 370 patients who underwent pancreatic resection surgery for various indications (84.3% in malignant indication) in a single surgery centre in Graz, Austria. The preoperative and postoperative diabetes statuses were evaluated according to surgery method and disease entity and predictors for diabetes development after surgery, as well as outcomes (survival and cancer recurrence) according to diabetes status, were analysed. In the entire cohort, the postoperative diabetes (postopDM) incidence was 29%. PostopDM occurred significantly more frequently in malignoma patients than in those with benign diseases (31.3% vs. 16.7%; p = 0.040, OR = 2.28). In the malignoma population, BMI, longer surgery duration, and prolonged ICU and hospital stay were significant predictors of diabetes development. The 1- and 2-year follow-ups showed a significantly increased mortality of people with postopDM in comparison to people without diabetes (HR 1-year = 2.02, p = 0.014 and HR 2-years = 1.56, p = 0.034). Local cancer recurrence was not influenced by the diabetes status. Postoperative new-onset diabetes seems to be associated with higher mortality of patients with pancreatic malignoma undergoing pancreatobiliary surgery.

Find related publications in this database (Keywords)

pancreatic cancer

pancreoprivic diabetes

pancreatobiliary surgery

diabetes type 3c

mortality

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