Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Groschner, K.
Arriving at the next level of complexity in IP₃R and SOCE signaling
CELL CALCIUM. 2023; 115: 102796 Doi: 10.1016/j.ceca.2023.102796
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Groschner Klaus

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Abstract:

The endoplasmic reticulum (ER) has long been recognized as the master regulator of cellular Ca2+ signaling. In this context, IP3R channels may be envisioned as this conductor's baton, which enables virtuous orchestration of cellular Ca(2+ )signaling tunes. IP(3)Rs serve the generation of spatiotemporally defined Ca2+ changes and are key for the ER ' s function as an autonomous Ca2+ signaling unit, which is able to govern its own refilling from the extracellular Ca2+ pool. As yet, IP3R signaling has been primarily attributed to its precisely-tunable Ca2+ channel function and IP3-mediated control over Ca2+ levels within signaling domains. A recent report from the Hasan laboratory [1] provides evidence for an as yet overlooked function of IP(3)R1 in terms of supporting STIM/Oraimediated SOCE in neurons. IP(3)R1 is demonstrated to remarkably facilitate productive STIM-Orai interactions and SOCE by a process that is triggered by IP3 but independent of the receptors' function as an ER Ca2+ channel.

Find related publications in this database (Keywords)

IP3R

SOCE

STIM-Orai coupling

Neuronal Ca(2+)signaling

ER-PM junctions

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