Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Schreiber, N; Reisinger, AC; Hatzl, S; Schneider, N; Scholz, L; Herrmann, M; Kolland, M; Schuller, M; Kirsch, AH; Eller, K; Kink, C; Fandler-Höfler, S; Rosenkranz, AR; Hackl, G; Eller, P.
Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients.
iScience. 2023; 26(10): 108044 Doi: 10.1016/j.isci.2023.108044 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Eller Philipp

Schreiber Nikolaus

Co-authors Med Uni Graz

Eller Kathrin

Fandler-Höfler Simon

Hackl Gerald

Hatzl Stefan

Herrmann Markus

Kirsch Alexander

Kolland Michael

Reisinger Alexander Christian

Rosenkranz Alexander

Schneider Nikolaus

Scholz Laura

Schuller Max

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Abstract:

Carbohydrate-deficient transferrin (CDT) and the γ-glutamyltransferase-CDT derived Anttila-Index are established biomarkers for sustained heavy alcohol consumption and their potential role to predict delirium and mortality in critically ill patients is not clear. In our prospective observational study, we included 343 consecutive patients admitted to our ICU, assessed the occurrence of delirium and investigated its association with biomarkers of alcohol abuse measured on the day of ICU admission. 35% of patients developed delirium during ICU stay. We found significantly higher CDT levels (p = 0.011) and Anttila-Index (p = 0.001) in patients with delirium. CDT above 1.7% (OR 2.06), CDT per percent increase (OR 1.26, AUROC 0.75), and Anttila-Index per unit increase (OR 1.28, AUROC 0.74) were associated with delirium development in adjusted regression models. Anttila-Index and CDT also correlated with delirium duration exceeding 5 days. Additionally, Anttila-Index above 4, Anttila-Index per unit increase, and CDT per percent increase were independently associated with hospital mortality.

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