Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Horvath, A; Zukauskaite, K; Hazia, O; Balazs, I; Stadlbauer, V.
Human gut microbiome: Therapeutic opportunities for metabolic syndrome-Hype or hope?
ENDOCRIN DIAB METAB. 2023; Doi: 10.1002/edm2.436 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Horvath Angela

Stadlbauer-Köllner Vanessa

Co-authors Med Uni Graz

Balazs Irina

Hazia Olha

Zukauskaite Kristina

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Abstract:

Shifts in gut microbiome composition and metabolic disorders are associated with one another. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Diet, intake of probiotics or prebiotics and faecal microbiome transplantation (FMT) are methods to alter a person's microbiome composition. Although FMT may allow establishing a proof of concept to use microbiome modulation to treat metabolic disorders, studies show mixed results regarding the effects on metabolic parameters as well as on the composition of the microbiome. This review summarizes the current knowledge on diet, probiotics, prebiotics and FMT to treat metabolic diseases, focusing on studies that also report alterations in microbiome composition. Furthermore, clinical trial results on the effects of common drugs used to treat metabolic diseases are synopsized to highlight the bidirectional relationship between the microbiome and metabolic diseases. In conclusion, there is clear evidence that microbiome modulation has the potential to influence metabolic diseases; however, it is not possible to distinguish which intervention is the most successful. In addition, a clear commitment from all stakeholders is necessary to move forward in the direction of developing targeted interventions for microbiome modulation. We reviewed clinical trials using diet, prebiotics, probiotics and faecal microbiota transplantation to treat metabolic syndrome via microbiome modulation. We also reviewed the effect of the most important drugs to treat metabolic syndrome on the microbiome. We conclude that microbiome modulation is a valuable therapeutic tool in metabolic syndrome but more research is needed to define the most useful therapeutic intervention.image

Find related publications in this database (Keywords)

diet

faecal microbiota transplantation

metabolic syndrome

microbiome

obesity

prebiotic

probiotic

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